KEGG   REACTION: R04854
Entry
R04854                      Reaction                               
Name
20alpha-hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
20alpha-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C05500 + C00007 + 2 C00662 + 2 C00080 <=> C05501 + C00001 + 2 C00667
Comment
second step of R02724 (R01454+R04854+R03933)
Reaction class
RC01223  C05500_C05501
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R04854  20alpha-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (396)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (395)   
All databases (411)   

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